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Unlocking the Science of Weight Loss Medications

Staff

Updated: Jul 20, 2024


Unlocking the Science of Weight Loss Medications

Weight loss medications have become a popular option for individuals looking to achieve their weight loss goals effectively and efficiently. Skinny Shot Wellness is at the forefront of this trend, offering cutting-edge compounds like compounded semaglutide and compounded tirzepatide to help clients on their weight loss journey.


Compounded semaglutide and tirzepatide are two medications that, when combined with a healthy diet and regular exercise, have been shown to aid in weight loss by targeting different pathways in the body. Semaglutide works by mimicking a hormone that helps regulate insulin levels, leading to reduced appetite and calorie intake. On the other hand, tirzepatide works by targeting multiple receptors in the body to reduce appetite and intake as well as regulate glucose and energy balance.


One of the key benefits of these weight loss medications is their ability to help individuals not only lose weight but also maintain their weight loss long-term. By targeting specific biological pathways related to weight regulation, compounded semaglutide and tirzepatide can provide more sustainable results compared to traditional diet and exercise regimens. It is important to note that while weight loss medications can be a valuable tool in achieving weight loss goals, they should be used in conjunction with a healthy lifestyle that includes a balanced diet and regular physical activity. Additionally, it is essential to consult with a healthcare provider before starting any weight loss medication to ensure it is safe and appropriate for individual health needs.


Semaglutide is the active ingredient found in brand name Ozempic® and Wegovy®. The brand name drugs are produced by and available exclusively from Novo Nordisk™, an American Pharmaceutical company. Semaglutide is only a GLP-1 agonist.


Tirzepatide is the active ingredient found in brand name Mounjaro® and Zepbound ™. The brand name drugs are produced by and available exclusively from Eli Lilly and Company™, an American Pharmaceutical company. Tirzepatide is both a GLP-1 agonist AND a GIP agonist, blocking both receptors. Tirzepatide, thanks to its dual agonist mechanism of action, showed greater weight loss in clinical trials than semaglutide- mean weight reduction of 21.1% (tirzepatide) vs 10-14% (semaglutide). Anecdotally, patients report significantly less side effects with tirzepatide leading to increased drug tolerability and follow through with treatment and results.


The science of weightloss

Both medications target an area of the brain that affects appetite and cravings and reduces these feedback mechanisms resulting in appetite suppression. They both increase insulin production from the pancreas and decrease glucagon production from the liver, leading to improved blood sugar management making you feel better and more stable throughout the day. By slowing down the digestion of your food, these medications help you feel full faster and stay full longer. This helps with portion control, overall calorie intake, and leads to weight loss. Tirzepatide has the added benefit of an increase in energy expenditure at the cellular level which aids in weight loss.


Some people may experience side effects with these medications, such as nausea, heartburn, indigestion, gas/bloating, constipation or diarrhea. Focusing on a protein forward diet with plenty of water and keeping your body moving can help alleviate or even prevent these symptoms. We also recommend pre and probiotic supplements and provide a more in depth nutrition guide to help you be successful and reach your goals.


REFERENCES


Azuri, Joseph, et al. “Tirzepatide versus semaglutide for weight loss in patients with type 2 diabetes mellitus: A value for money analysis.” Diabetes, Obesity and Metabolism, vol. 25, no. 4, 27 Dec. 2022, pp. 961–964, https://doi.org/10.1111/dom.14940.


De Block, Christophe, et al. “Tirzepatide for the treatment of adults with type 2 diabetes: An endocrine perspective.” Diabetes, Obesity and Metabolism, vol. 25, no. 1, 31 Aug. 2022, pp. 3–17, https://doi.org/10.1111/dom.14831.

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